DBCO-Dap(m-PEG4)-Gly-Gly-Phe-Gly-PAB(m-PEG8)-Exatecan Size:25mg NCCCCCNC(=O)C1=CC=C2C(=O)OC3(C2=C1)C1=CC=C(O)C=C1OC1=C3C=CC(O)=C1 Purity (HPLC): ≥ 95%

NCCCCCNC(=O)C1=CC=C2C(=O)OC3(C2=C1)C1=CC=C(O)C=C1OC1=C3C=CC(O)=C1 Purity (HPLC): ≥ 95% Shipping Conditions: room temperature Storage Conditions: Refrigerated Regulatory Statement: For Research Use Only

ACS Chemical Biology 2020

987 Purity (HPLC) >= 95% Solubility DMSO

Product Name Lenalidomide-CO-C6-Br Synonyms Lenalidomide-4'-CO-C6-Br CAS Number n/a Related CAS Molecular Formula C20H24BrN3O4 Molecular Weight 450

DBCO-Dap(m-PEG4)-Gly-Gly-Phe-Gly-PAB(m-PEG8)-Exatecan Size:25mg NCCCCCNC(=O)C1=CC=C2C(=O)OC3(C2=C1)C1=CC=C(O)C=C1OC1=C3C=CC(O)=C1 Purity (HPLC): ≥ 95%SOLU KNEX cleavable linker features a Gly Gly Phe Gly (GGFG) peptide. In this product, a DBCO Dap(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. DBCO is a strained alkyne commonly used in copper free click chemistry, specifically in the strain promoted azide alkyne cycloaddition (SPAAC) reaction. Additionally, m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to