Azide-Hexanoyl-Val-Cit-PAB(m-PEG8)-Exatecan Size:5mg 475 SMILES BrCCOCCOCCOCCOCCOCCCC1=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC)

475 SMILES BrCCOCCOCCOCCOCCOCCCC1=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

Product Name DOTA-C6-amine Synonyms CAS Number n/a Related CAS Molecular Formula C22H42N6O7 Molecular Weight 502

CN(C)C1=CC=C2C(OC3=CC(C=CC3=C2[C+]2=CC=C(C=C2C([O-])=O)C(=O)NCCOCCOCCOCCN=[N]#N)=[N+](C)C)=C1 Purity (HPLC): ≥ 95% Shipping Conditions: room temperature Storage Conditions: Refrigerated Regulatory Statement: For Research Use Only

Product Name Azide-Lys(m-PEG4)-Val-Ala-PAB(m-PEG8)-Exatecan Synonyms CAS Number Related CAS Molecular Formula C74H106FN11O23 Molecular Weight 1536

Azide-Hexanoyl-Val-Cit-PAB(m-PEG8)-Exatecan Size:5mg 475 SMILES BrCCOCCOCCOCCOCCOCCCC1=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC)SOLU KNEX cleavable linker features a Val Cit dipeptide. m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is Exatecan, a highly potent topoisomerase I inhibitor derived from camptothecin, which induces DNA damage by stabilizing the topoisomerase IDNA complex, resulting in cell cycle arrest and apoptosis. Derived from established ADC linker architectures, SOLU KNEX ADC