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21 Purity (HPLC) >= 95% Solubility DMSO
Product Name Mal-Propionyl-Dap(m-PEG4)-Val-Ala-PAB(m-PEG8) Synonyms CAS Number Related CAS Molecular Formula C53H87N7O21 Molecular Weight 1158
Product Name DOTA-tris(t-Bu)ester-NHS Synonyms CAS Number 819869-77-7 Related CAS Molecular Formula C32H55N5O10 Molecular Weight 669
a reaction where tetrazine compounds react with strained dienophiles
Mal-Acetyl-Beta-Ala-Val-Ala-PAB(m-PEG8)-Exatecan Size:5mg 21 Purity (HPLC) >= 95%SOLU KNEX cleavable linker features a Val Ala dipeptide. In this product, m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is Exatecan, a highly potent topoisomerase I inhibitor derived from camptothecin, which induces DNA damage by stabilizing the topoisomerase IDNA complex, resulting in cell cycle arrest and apoptosis. Derived from established ADC linker architectures,
