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Product Name 1-(methoxy-d3)-3-nitrobenzene Synonyms 1-(²H3)methoxy-3-nitrobenzene CAS Number n/a Related CAS Molecular Formula C7H7NO3 Molecular Weight 156
Single isomer 5-FAM PEG3 alkyne
527 SMILES [N-]=[N+]=NCCOCCOCCOCCOCCNC1=CC=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only
1038/s41586-020-2760-4
DBCO-Hexanoyl-Val-Cit-PAB(m-PEG8)-Exatecan Size:25mg Product Name 1-(methoxy-d3)-3-nitrobenzene Synonyms 1-(²H3)methoxy-3-nitrobenzeneSOLU KNEX cleavable linker features a Val Cit dipeptide. m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is Exatecan, a highly potent topoisomerase I inhibitor derived from camptothecin, which induces DNA damage by stabilizing the topoisomerase IDNA complex, resulting in cell cycle arrest and apoptosis. Derived from established ADC linker architectures, SOLU KNEX ADC
