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This workflow suggested dose-response testing using iPSC-CMs to study cardiovascular toxicity related to chronic heart failure and cardiac dysfunction, viability and proliferation assays of iPSC-derived endothelial cells/vascular smooth muscle cell co-cultures to study atherosclerotic phenotypes, and iPSC-derived immune cell/cardiomyocyte co-cultures with viability, electrophysiology, and immune cell assays to study effects such as hyper-eosinophilic cardiac toxicity, myocarditis, and pericarditis
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